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nd
NICE clinical guideline 127
What this presentation covers
Five clinical case scenarios, including:
presentation
medical history
The clinical decisions surrounding diagnosis and
management will then be examined
Presentation
38 year old, attending for routine appointment about her contraception, for
which she uses a diaphragm.
Medical history
From her records you notice that Mary’s blood pressure has increased since
her last check twelve months ago. She does not smoke, drinks 10-12 units of
alcohol a week and has no notable medical history.
On examination
Mary’s first clinic blood pressure measurement is 158/94 mmHg. Her heart rate
is 72 beats per minute and regular
You are considering a diagnosis of hypertension and therefore take another
reading in Mary’s other arm. There is no notable difference between readings.
Next steps for diagnosis
Question 1.
What would you do next?
Answer 1.
You would take Mary’s blood pressure a third time during the consultation.
Question 1.
The third reading is 149/93 mmHg. You suspect hypertension – what would you do
next?
Answer 1.2 (continued)
test for the presence of protein in the urine by sending a urine sample for
estimation of the albumin:creatinine ratio and test for haematuria using a
reagent strip
take a blood sample to measure plasma glucose, electrolytes, creatinine,
estimated glomerular filtration rate, serum total cholesterol and HDL cholesterol
examine the fundi for the presence of hypertensive retinopathy
arrange for a 12-lead electrocardiograph to be performed.
Answer 1.2 (continued)
You would also carry out a formal assessment of cardiovascular risk
(Mary’s clinic blood pressure must be used in the calculation of
cardiovascular risk) using a cardiovascular risk assessment tool, in line with
Identification and assessment of CVD risk in ‘Lipid modification’
(NICE clinical guideline 67).
Additionally, you would also ascertain information about lifestyle in areas
such as diet, exercise, alcohol, smoking and caffeine consumption and
dietary sodium intake and offer appropriate lifestyle
advice.
Record the results of all investigations and assessment in
Mary’s notes.
Answer 1.
You would advise that healthy diet and regular exercise can reduce blood
pressure. You would also encourage her to keep her dietary sodium intake
low as this can reduce blood pressure. You should also inform her about
local initiatives
Question 1.
The result of Mary’s ABPM shows daytime average blood pressure of
145/92 mmHg.
What would your diagnosis and your next steps be?
Question 1.
The results of the investigations for target organ damage and formal
assessment of cardiovascular risk are:
no evidence of target organ damage
10-year cardiovascular risk less than 20%.
Nothing abnormal was detected in the other investigations you organised.
What is your next step and what treatment and follow up would you offer?
Answer 1.
Further assessment
You would consider seeking specialist evaluation of secondary causes of
hypertension and a more detailed assessment of potential target organ
damage. This is because 10-year cardiovascular risk assessments can
underestimate the lifetime risk of cardiovascular events in these people.
Additionally, people under 40 years with stage 1 hypertension are less likely to
have overt evidence of target organ damage or vascular disease.
Question 1.
If Mary had been eligible to receive antihypertensive drug treatment, what
should you consider when prescribing antihypertensive drugs for a woman of
child-bearing potential?
Answer 1.
There is an increased risk of congenital abnormalities if women take angiotensin-
converting enzyme (ACE) inhibitors or angiotensin III receptor blockers (ARBs)
during pregnancy, and it is important that women of child-bearing age know this. If
the woman is planning a pregnancy she should discuss this with you. If a woman
taking ACE inhibitors or ARBs becomes pregnant, these antihypertensive drugs
should be stopped and alternatives offered.
Link to related recommendations from the ‘Hypertension in Pregnancy’ (NICE
clinical guideline 107):
Question 1.
What are the key points to remember when measuring blood
pressure to ensure that the reading is as accurate
as possible?
Case scenario 2 : Danny
Presentation
Danny is a 39-year-old black male of Caribbean family origin. He presents to you
with a sore ankle after ‘going over’ on it.
Medical history
Danny has no significant past medical history. Previous presentations have been
related to coughs and colds.
He smokes 25 cigarettes a day, alcohol consumption around 20 units/week and has
done for 18 years. He works shifts and says that he considers his diet to be
unhealthy as a result.
On examination
You conclude that Danny’s ankle is sprained. As part of your routine examination
you measure his blood pressure. The first measurement in
his left arm is 150/92 mmHg, the second measurement in his right
arm is 149/91 mmHg and the third measurement in his left
arm is 151/92 mmHg.
Question 2.
What would you do next?
Case scenario 2 : Danny
Answer 2.
You would record Danny’s clinic blood pressure as 149/91 mmHg. In order to
diagnose hypertension, you organise ambulatory blood pressure monitoring
(ABPM) to confirm a diagnosis of hypertension. When organising this you
ensure that at least two measurements per hour are taken during Danny’s
usual waking hours. You would use the average value of at least
14 measurements taken during Danny’s usual waking hours to confirm a
diagnosis of hypertension.
At the same time you would also carry out investigations for target organ
damage (such as left ventricular hypertrophy, chronic kidney disease and
hypertensive retinopathy).