WEGENER’S
GRANULOMATOSIS
(GRANULOMATOSIS WITH
POLYANGIITIS)
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Wegener's Granulomatosis: Etiology, Clinical Features, Diagnosis, and Treatment, Slides of Pathology
Wegener's granulomatosis, also known as granulomatosis with polyangiitis, is an uncommon immune-based inflammatory necrotizing vasculitis. An overview of the etiology, clinical features, differential diagnosis, histopathology, diagnosis, and treatment of wegener's granulomatosis. The condition typically affects the upper respiratory tract, lungs, and kidneys, and can manifest in various ways, including oral cavity alterations, head and neck symptoms, and renal and lung lesions. Diagnosis is often made through biopsy and the presence of positive antineutrophil cytoplasmic antibodies (cancas). Treatment typically involves cyclophosphamide and prednisone.
Typology: Slides
2023/2024
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WEGENER’S
GRANULOMATOSIS
(GRANULOMATOSIS WITH
POLYANGIITIS)
ETIOLOGY
- (^) Uncommon immune-bases inflammatory necrotizing
vasculitis whose exact cause is unknown.
CLINICAL DIFFERENTIAL DIAGNOSIS
- (^) F ungal disease
- (^) L ymphoma
- (^) L angerhans cell disease
- (^) I nfectious granulomatous disease
- (^) P eripheral giant cell lesion
- (^) P yogenic granuloma
- (^) N ecrotizing sialometaplasia
- (^) S quamous cell carcinoma
IT CAN ALSO BE MANIFESTED IN THE:
HEAD AND NECK
- (^) swelling of the parotid gland
- (^) facial edema
- (^) sinusitis
- (^) rhinorrhea
- nasal stuffiness
- (^) epistaxis
- it also manifest necrosis and
perforation of the nasal septum or
palate
KIDNEY
- (^) these disease manifest focal
necrotizing glomerulitis which later
results to renal failure
LUNGS
presence of lesions can be
detected from to light to severe
that may eventually lead to
respiratory failure.
DIAGNOSIS
- (^) Biopsy