42-year old
Male
Desk job
Frequent long haul flights for
work
↓ Muscle motion/ Prolonged immobility
Stasis of venous blood flow
Clot formation in leg veins
Thrombus dislodges/ embolizes to the lungs
Inferior vena cava
Right atrium
Right ventricle
Pulmonary vasculature
(Embolus may lodge on different
parts depending on its size)
Saddle embolus
(Pulmonary artery
obstruction)
↓ Pulmonary
arterial/arteriolar blood
flow
Ischemia/infarct of
sub-pleural tissue
↑Hydrostatic pressure
in capillaries
Transudation of fluid
into the interstitial fluid
Swelling of the over
the left calf
Exerts pressure on
nearby tissues
Tenderness over
the left calf
Positive Homan’s sign
↓Delivery of
deoxygenated blood to
alveoli
↓CO2 delivery to lungs for
exhalation
↑CO2 in blood
↓O2 in blood
Medullary receptors
triggered
Aortic/carotid receptors
send signal to the brain
↑ RR
(26 breaths/min)
Tachypnea
Mild accessory
muscle use
↑ HR
(118 bpm)
Severe V/Q
mismatch
↑ Resistance
in the
pulmonary
circulation
Hypoxemia
Tachycardia
Right
ventricular
strain
Irritation of somatic
nerve endings on
parietal pleural
membrane
Shortness of breath
Pleuritic (sharp)
chest pain
worsened by deep
respiration
Stimulation of
adrenergic response
Risk Factors
Pathogenesis
Manifestations
Legends:
