




























































































Study with the several resources on Docsity
Earn points by helping other students or get them with a premium plan
Prepare for your exams
Study with the several resources on Docsity
Earn points to download
Earn points by helping other students or get them with a premium plan
Community
Ask the community for help and clear up your study doubts
Discover the best universities in your country according to Docsity users
Free resources
Download our free guides on studying techniques, anxiety management strategies, and thesis advice from Docsity tutors
pharmacology,medical and surgical 2nd year college
Typology: Cheat Sheet
1 / 178
This page cannot be seen from the preview
Don't miss anything!
Dr. Ding Villanueva PharmD, MHA, RPh, RN Lecturer, Riverside College
Pharmacokinetics refers to how medications travel through the body. They undergo a variety of biochemical processes that result in absorption, distribution, metabolism, and excretion.
Subcutaneous, intramuscular BARRIERS TO ABSORPTION: Capillary walls have large spaces between cells. Therefore, there is no significant barrier. ABSORPTION PATTERN ● (^) Solubility of the medication in water: Highly soluble medications have rapid absorption (10 to 30 min); poorly soluble medications have slow absorption. ● (^) Blood perfusion at the site of injection: sites with high blood perfusion have rapid absorption; sites with low blood perfusion have slow absorption.
● Increase in some medication-metabolizing enzymes: This can metabolize a particular medication sooner, requiring an increase in dosage of that medication to maintain a therapeutic level. It can also cause an increase in the metabolism of other concurrent-use medications. ● First-pass effect: The liver inactivates some medications on their first pass through the liver, and thus they require a nonenteral route (sublingual, IV) because of their high first-pass effect. ● Similar metabolic pathways: When the same pathway metabolizes two medications, it can alter the metabolism of one or both of them. In this way, the rate of metabolism can decrease for one or both of the medications, leading to medication accumulation. ● Nutritional status: Clients who are malnourished can be deficient in the factors that are necessary to produce specific medication-metabolizing enzymes, thus impairing medication metabolism.