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Multiple Sclerosis: Types, Symptoms, Testing, Diagnosis, and Treatment, Study notes of Health sciences

An overview of Multiple Sclerosis (MS), an autoimmune disease that attacks the myelin sheath surrounding nerves in the CNS. It explains the four types of MS, their symptoms, testing methods, diagnosis, and treatment options.

Typology: Study notes

2022/2023

Available from 05/04/2023

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MS:
- Multiple Sclerosis is an autoimmune disease.
- Body’s own immune system attacks the myelin sheath surrounding nerves in the CNS.
- This produces inflammation and scar tissue as the body tries to repair the damage.
- Characteristic plaques may show up in an MRI scan
- Demyelination of nerves slow or may stop nerve impulse
FOUR TYPES OF MS:
- Relapsing-Remitting. Most common form. Flare-ups or exacerbations are
followed by periods of remission
- Secondary-Progressive. Begins as relapsing-remitting MS. Symptoms worsen
steadily over time with or without relapses.
- Progressive-Relapsing. Rare form characterized by steadily worsening disease
with occasional relapses.
- Primary-Progressive. Slowly worsening symptoms with no periods of remission.
This type is not common.
SYMPTOMS:
- Symptoms may be varied and occur at different
time intervals
- Symptoms include fatigue, dizziness, visual
blurring, sensory disturbances including tingling
and numbness
- Over time motor skills may become impaired
- advanced cases bladder dysfunction may occur
as well as mental impairment
TESTING:
- Lumbar Puncture
- Checking for elevated protein levels due to
the autoimmune nature of the disease
- Evoked Potential
- Time for a sensory stimulus to travel
- Use of EEG (electroencephalograph)
- MRI scan to detect plaques in the CNS
DIAGNOSIS:
- Typically difficult to diagnose
- CNS plaques may not appear for years
- Diagnosis is based on patient’s symptoms and Testing
TREATMENT:
- Steroids or anti-inflammatory drugs shorten duration of attack
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MS:

  • Multiple Sclerosis is an autoimmune disease.
  • Body’s own immune system attacks the myelin sheath surrounding nerves in the CNS.
  • This produces inflammation and scar tissue as the body tries to repair the damage.
  • Characteristic plaques may show up in an MRI scan
  • Demyelination of nerves slow or may stop nerve impulse FOUR TYPES OF MS:
  • Relapsing-Remitting. Most common form. Flare-ups or exacerbations are followed by periods of remission
  • Secondary-Progressive. Begins as relapsing-remitting MS. Symptoms worsen steadily over time with or without relapses.
  • Progressive-Relapsing. Rare form characterized by steadily worsening disease with occasional relapses.
  • Primary-Progressive. Slowly worsening symptoms with no periods of remission. This type is not common. SYMPTOMS:
  • Symptoms may be varied and occur at different time intervals
  • Symptoms include fatigue, dizziness, visual blurring, sensory disturbances including tingling and numbness
  • Over time motor skills may become impaired
  • advanced cases bladder dysfunction may occur as well as mental impairment TESTING:
  • Lumbar Puncture
  • Checking for elevated protein levels due to the autoimmune nature of the disease
  • Evoked Potential
  • Time for a sensory stimulus to travel
  • Use of EEG (electroencephalograph)
  • MRI scan to detect plaques in the CNS DIAGNOSIS:
  • Typically difficult to diagnose
  • CNS plaques may not appear for years
  • Diagnosis is based on patient’s symptoms and Testing TREATMENT:
  • Steroids or anti-inflammatory drugs shorten duration of attack
  • Disease-modifying treatments (DMTs)
  • Limit progression of the disease
  • include interferons
  • Beta Interferons suppress the body’s immune system to decrease attack against myelin
  • Monoclonal Antibodies
  • Target proteins involved in the autoimmune attack
  • Supportive treatment as needed