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Cardiovascular System transes, Study notes of Anatomy

reviewer for the heart. Anatomy and physiology transes, parts of heart and their uses.

Typology: Study notes

2021/2022

Available from 07/24/2023

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The Cardiovascular System
The heart is a muscular organ that is
essential for life because it pumps blood
through the body.
The heart is a member organ of the
cardiovascular system, which consists of
the
heart, blood vessels, and blood.
The heart of a healthy adult, at rest, pumps
approximately 5 liters (L) of blood per
minute.
For most people, the heart continues to
pump at approximately that rate for more
than 75 years.
The Cardiovascular System
The heart is a member organ of the
cardiovascular system, which consists of
the heart, blood vessels, and blood.
The heart is actually two pumps in one,
with the heart’s right side pumping to the
lungs and back to the left side of the heart
through vessels of the pulmonary
circulation.
The left side of the heart pumps blood to all
other tissues of the body and back to the
right side of the heart through vessels of the
systemic circulation.
The Cardiovascular System
The heart is a member organ of the
cardiovascular system, which consists of
the heart, blood vessels, and blood.
The heart is actually two pumps in one,
with the heart’s right side pumping to the
lungs and back to the left side of the heart
through vessels of the pulmonary
circulation.
The left side of the heart pumps blood to all
other tissues of the body and back to the
right side of the heart through vessels of the
systemic circulation.
Functions of the Heart
1. Generates blood pressure
2. Routes blood
3. Ensures one-way blood flow
4. Regulates blood supply
Heart Characteristics
Size: size of a fist and weighs
less than 1 lb.
Location: between lungs in thoracic cavity
Orientation: apex (bottom) towards left side
Pericardia
Pericardium: double-layered sac that
anchors and protects heart
Parietal pericardium: membrane around heart’s
cavity
Visceral pericardium: membrane on heart’s
surface
Pericardial cavity: space around heart
Heart External Anatomy
A coronary sulcus extends around the heart,
separating the atria from the ventricles.
Two grooves, or sulci, which indicate the
division between the right and left ventricles,
extend inferiorly from the coronary sulcus.
The anterior interventricular sulcus extends
inferiorly from the coronary sulcus on the
anterior surface of the heart.
Heart External Anatomy
The pulmonary trunk, arising from the right
ventricle, splits into the right and left pulmonary
arteries, which carry blood to the lungs.
The aorta arising from the left ventricle, carries
blood to the rest of the body.
Heart Chambers
Four Chambers:
• left atrium (LA)
• right atrium (RA)
• left ventricle (LV)
• right ventricle (RV)
Coronary sulcus:
• separates atria from ventricles
The Atria
Superior chambers
Holding chambers
Small, thin walled
Contract minimally to push blood into ventricles
Interatrial septum:
• separates right and left atria
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The Cardiovascular System The heart is a muscular organ that is essential for life because it pumps blood through the body. The heart is a member organ of the cardiovascular system, which consists of the heart, blood vessels, and blood. The heart of a healthy adult, at rest, pumps approximately 5 liters (L) of blood per minute. For most people, the heart continues to pump at approximately that rate for more than 75 years. The Cardiovascular System The heart is a member organ of the cardiovascular system, which consists of the heart, blood vessels, and blood. The heart is actually two pumps in one, with the heart’s right side pumping to the lungs and back to the left side of the heart through vessels of the pulmonary circulation. The left side of the heart pumps blood to all other tissues of the body and back to the right side of the heart through vessels of the systemic circulation. The Cardiovascular System The heart is a member organ of the cardiovascular system, which consists of the heart, blood vessels, and blood. The heart is actually two pumps in one, with the heart’s right side pumping to the lungs and back to the left side of the heart through vessels of the pulmonary circulation. The left side of the heart pumps blood to all other tissues of the body and back to the right side of the heart through vessels of the systemic circulation. Functions of the Heart

  1. Generates blood pressure
  2. Routes blood
  3. Ensures one-way blood flow
  4. Regulates blood supply Heart Characteristics Size: size of a fist and weighs less than 1 lb. Location: between lungs in thoracic cavity Orientation: apex (bottom) towards left side Pericardia Pericardium: double-layered sac that anchors and protects heart Parietal pericardium: membrane around heart’s cavity Visceral pericardium: membrane on heart’s surface Pericardial cavity: space around heart Heart External Anatomy A coronary sulcus extends around the heart, separating the atria from the ventricles. Two grooves, or sulci, which indicate the division between the right and left ventricles, extend inferiorly from the coronary sulcus. The anterior interventricular sulcus extends inferiorly from the coronary sulcus on the anterior surface of the heart. Heart External Anatomy The pulmonary trunk, arising from the right ventricle, splits into the right and left pulmonary arteries, which carry blood to the lungs. The aorta arising from the left ventricle, carries blood to the rest of the body. Heart Chambers Four Chambers:
    • left atrium (LA)
    • right atrium (RA)
    • left ventricle (LV)
    • right ventricle (RV) Coronary sulcus:
    • separates atria from ventricles The Atria Superior chambers Holding chambers Small, thin walled Contract minimally to push blood into ventricles Interatrial septum:
    • separates right and left atria

Ventricles Inferior chambers Pumping chambers Thick, strong walled Contract forcefully to propel blood out of heart Interventricular septum:

  • separates right and left ventricles Atrioventricular Heart Valves Valves between the atria and ventricles Tricuspid valve:
  • AV valve between RA and RV
  • 3 cusps Bicuspid valve (mitral):
  • AV valve between LA and LV
  • 2 cusps Valvular Control Each ventricle contains cone-shaped, muscular pillars called papillary muscles. These muscles are attached by strong, connective tissue strings called chordae tendineae to the free margins of the cusps of the atrioventricular valves. When the ventricles contract, the papillary muscles contract and prevent the valves from opening into the atria by pulling on the chordae tendineae attached to the valve cusps. Semilunar Heart Valves The semilunar valves have three half-moon shaped cusps, and are valves between the pulmonary trunk and aorta. Pulmonary valve:
  • between RV and pulmonary trunk Aortic valve:
  • between LV and aorta Blood Flow through Heart
  1. RA
  2. Tricuspid valve
  3. RV
  4. Pulmonary semilunar valve
  5. Pulmonary trunk
  6. Pulmonary arteries
  7. Lungs
  8. Pulmonary veins
  9. LA
  10. Bicuspid valve
  11. LV
  12. Aortic semilunar valve
  13. Aorta
  14. Body Blood Supply to the Heart Coronary arteries:
    • supply blood to heart wall
    • originate from base of aorta (above aortic semilunar valve) Left coronary artery:
    • has 3 branches
    • supply blood to anterior heart wall and left ventricle Blood Supply to the Heart Right coronary artery:
    • originates on right side of aorta
    • supply blood to right ventricle Cardiac veins:
    • drain blood from the cardiac muscle
    • parallel to the coronary arteries
    • most drain blood into the coronary sinus
    • from the coronary sinus into the right atrium Heart Wall Epicardium:
    • surface of heart (outside) Myocardium:
    • thick, middle layer composed of cardiac muscle Endocardium:
    • smooth, inner surface Cardiac Muscle 1 Centrally located nucleus Branching cells Rich in mitochondria Striated (actin and myosin) Ca2+ and ATP used for contractions Intercalated disks connect cells Figure 12. (b) ©Ed Reschke Cardiac Muscle Action Potentials Changes in membrane channels’ permeability are responsible for producing action potentials and is called pacemaker potential.
    1. Depolarization phase:
    • Na+ channels open
    • Ca2+ channels open
    1. Plateau phase:
    • Na+ channels close
    • Some K+ channels open
    • Ca2+ channels remain open

Cardiac Cycle The cardiac cycle is a summative description of all the events that occur during one single heartbeat. The heart is a two sided pump, with the atria being primers for pumps and the ventricles being the actual pumps. Heart Chamber Contractions Cardiac muscle contractions produce pressure changes within heart chambers. Pressure changes are responsible for blood movement. Blood moves from areas of high to low pressure. Cardiac Cycle Atrial systole:

  • contraction of atria Ventricular systole:
  • contraction of ventricles Atrial diastole:
  • relaxation of atria Ventricular diastole:
  • relaxation of ventricles Heart Sounds Heart sounds are produced due to the closure of heart valves. A stethoscope is used to hear heart sounds The first heart sound makes a ‘lubb’ sound. The second heart sound makes a ‘dupp’ sound. The first heart sound is due to the closure of the atrioventricular valves. The second heart sound is due to the closure of the semilunar valves. Regulation of Heart Function Stroke Volume:
  • volume of blood pumped per ventricle per contraction
  • 70 milliliters/beat Heart Rate:
  • number of heart beats in 1 min.
  • 72 beats/min. Regulation of Heart Function Cardiac Output:
  • volume of blood pumped by a ventricle in 1 min. Intrinsic Regulation of the Heart Intrinsic regulation refers to the mechanisms contained within the heart itself that control cardiac output. Venous return:
    • the amount of blood that returns to heart Preload:
    • the degree ventricular walls are stretched at end of diastole Venous return, preload, and stroke volume are related to each other Intrinsic Regulation of the Heart Starlings Law of the Heart:
    • relationship between preload and stroke
    • volume
    • influences cardiac output
    • Example - exercise increases venous return, preload, stroke volume, and cardiac output After load:
    • pressure against which ventricles must pump blood Extrinsic Regulation of Heart Extrinsic regulation refers to mechanisms external to the heart, such as either nervous or chemical regulation. Nervous system control of the heart occurs through the sympathetic and parasympathetic divisions of the autonomic nervous system. influences of heart activity are carried through the autonomic nervous system. Both sympathetic and parasympathetic nerve fibers innervate the SA node. Baroreceptor Reflex The baroreceptor reflex is a mechanism of the nervous system that plays an important role in regulating heart function. Baroreceptors:
    • monitor blood pressure in the aorta and carotid arteries
    • changes in blood pressure cause changes in
    • frequency of action potentials
    • involves the medulla oblongata Chemoreceptor Reflex The chemoreceptor reflex involves chemical regulation of the heart.
  • 5 Liters/min. Cardiac output equals stroke volume multiplied times heart rate CO = SV x HR Chemoreceptor Reflex Chemical actions:
  • epinephrine and norepinephrine from the adrenal medulla can increase heart rate and stroke volume
  • excitement, anxiety, and anger can increase cardiac output
  • depression can decrease cardiac output
  • medulla oblongata has chemoreceptors for changes in pH and CO
  • K+, Ca2+, and Na+ affect cardiac function Heart Disease Coronary Artery Disease
  • due to decrease blood supply to the heart
  • coronary arteries are narrowed for some reason Myocardial Infarction (heart attack)
  • due to closure of one or more coronary arteries
  • area(s) of cardiac muscle lacking adequate blood supply die, and scars (infarct) Heart Procedures Angioplasty:
  • procedure opens blocked blood vessels Stent:
  • structures inserted to keep vessels open Bypass:
  • procedure reroutes blood away from blocked arteries Chemicals can affect heart rate and stroke volume.