Download AAB MT Exam Hem Coagulation Questions And Answers and more Exams Hematology in PDF only on Docsity!
And Answers
Primary hemostasis is maintained by what three factors? - correct answer ✅Vasoconstriction, Primary or Reversible platelet adhesion to subendothelium, and Secondary or Irreversible platelet aggregation. Secondary platelet aggregation is visually characterized by what? - correct answer ✅A change in platelet shape. During Secondary platelet aggregation, what is secreted? - correct answer ✅ADP, ATP, Epinephrine, Serotonin, and Platelet Factor 4. In the Common Pathway, when is prothrombinase complex formed? - correct answer ✅After the activation of factor X (this includes Xa,- Va-Ca++-platelet PL. In Hemophilia A patients the PT time is? - correct answer ✅Normal
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In Hemophilia A patients the PTT time is? - correct answer ✅Prolonged In Hemophilia A patients the bleed time is? - correct answer ✅Normal In Hemophilia A patients Factor VIII activity is? - correct answer ✅Decreased In Hemophilia A patients platelet function is? - correct answer ✅Normal Hemophilia A patients can be treated with what? - correct answer ✅Factor VIII concentrate or Cryoprecipitate What factor is deficient in Hemophilia B patients? - correct answer ✅Factor IX In Hemophilia B patients the PTT time is? - correct answer ✅Prolonged
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Hemophilia C patients can be treated with? - correct answer ✅Fresh Frozen Plasma Coagulation instruments, generally measure which factor as an endpoint? - correct answer ✅Factor V Factor I is known as? - correct answer ✅Fibrinogen Factor II is known as? - correct answer ✅Prothrombin Factor III is known as? - correct answer ✅Tissue Thromboplastin Factor IV is known as? - correct answer ✅Calcium
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Factor VI is known as? - correct answer ✅Labile Factor Factor VII is known as? - correct answer ✅Stable Factor Factor VIII is known as? - correct answer ✅Anti-hemophiliac Factor A Factor IX is known as? - correct answer ✅Anti-hemophiliac Factor B Factor X is known as? - correct answer ✅Stuart-Prower Factor Factor XI is known as? - correct answer ✅Anti-hemophiliac Factor C Factor XII is known as? - correct answer ✅Hageman Factor
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Which Coagulation Factors Groups are stored in the plasma? - correct answer ✅Fibrinogen Group, Prothrombin Group, and Contact Group. Which Coagulation Factors Groups are stored in the serum? - correct answer ✅Prothrombin Group and Contact Group. What is the inactive form of Plasmin? - correct answer ✅Plasminogen Fibrin is broke down by what? - correct answer ✅Plasmin What is the name for the process that breaks down fibrin? - correct answer ✅Fibrinogenolysis What biproduct is produced whenever crosslinked fibrin is broken down? - correct answer ✅X-oligomers D-dimers
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Prothrombin Time (PT) screening tests are designed to ascertain what? - correct answer ✅Factor deficiencies in the extrinsic/common pathway & to monitor oral anticoagulant therapy (warfarin and coumadin). What is the standard used to calculate/report INR? - correct answer ✅ISI = 1.0 (AAB exam) What coagulation methods can be used to detect clots? - correct answer ✅Optical method and Electromechanical method What is the AAB reference range for Prothrombin time (PT)/INR? - correct answer ✅10-13 seconds What does a prolonged prothrombin time (PT) suggest? - correct answer ✅Factors V, VII, X, II, or I deficiencies or the presence of an inhibitor.
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A prolonged APTT test suggests? - correct answer ✅A Factor I, II, V, VIII, X, IX, XI or XII deficiency or the presence of an inhibitor. What does the coagulation test TT stand for? - correct answer ✅Thrombin Time What does the TT test measure? - correct answer ✅The conversion of fibrinogen to fibrin. What reagent is used in the TT test? - correct answer ✅Thrombin What clot detection methods are used in the TT test? - correct answer ✅Optical method and Electromechanical method What is the AAB's reference range for the TT test? - correct answer ✅10-16 seconds
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What does a prolonged TT time suggest? - correct answer ✅1. Afibrinogenmia/Hypofibrinogemia/Dysfibrinogenemia
- Presence of Heparin
- Presence of FDPs 4.Thrombolytic Therapy What does the Fibrinogen test measure? - correct answer ✅Fibrin Clot Formation What reagent is used in the Fibrinogen test? - correct answer ✅Thrombin added to known concentrations of fibrinogen. How is the clot detected in the Fibrinogen test? - correct answer ✅Fibrin clotting times are graphed using 1: standard dilution. Fibrinogen concentration is ____________ ________________ to the clotting time. - correct answer ✅Inversely proportional
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Mixing studies calls for what type of dilution? - correct answer ✅1:2 dilution of patient's plasma mixed with normal pooled plasma. How are corrected results interpreted in a mixing study? - correct answer ✅As a factor deficiency. The next step is to perform a factor assay/ How are uncorrected results interpreted in a mixing study? - correct answer ✅As a circulating or specific factor inhibitor. The next step is to identify the inhibitor. What is the AAB's normal factor activity reference range? - correct answer ✅50-150% Why is the Factor Assay performed? - correct answer ✅To confirm a specific factor deficiency and to determine factor activity.
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What is the principle of a Factor Assay? - correct answer ✅Ability of patient's plasma to correct a prolonged PT or APTT of a known factor-deficient plasma (substrate). The results of a Factor Assay that detects a factor deficiency should be what? - correct answer ✅Linear If the Factor Assay result is not linear, what does this suggests? - correct answer ✅An inhibitor The one stage assay PT based factor assay includes? - correct answer ✅The extrinsic (F-VII) and common pathway (F- II, V, and X). The one stage assay APTT based factor assay includes? - correct answer ✅The intrinsic pathway (V- VIII, IX, XI, and XII). How is the standard curve constructed in the Factor Assays test? - correct answer ✅From 1:10. 1:20, and 1:40 dilutions
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Platelet function is ________________ in patient's with Hemophilia A. - correct answer ✅Normal How is Hemophilia A inherited? - correct answer ✅Recessive Fibrinogen deficiency disease may be caused by? - correct answer ✅Afibrinogenemia, Hypofibrinogenemia, or Dysfibrinogenemia. A prolonged PT, APTT, and minuscule levels of fibrinogen indicates which fibrinogen deficiency disease? - correct answer ✅Afibrinogenemia A prolonged PT, APTT, and decreased levels of fibrinogen indicates which fibrinogen deficiency disease? - correct answer ✅Hypofibrinogenemia
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A prolonged PT, APTT, and normal levels of fibrinogen indicated which fibrinogen deficiency disease? - correct answer ✅Dysfibrinogenemia Factor VIII deficiency is treated how? - correct answer ✅FFP and cryopercipitate What are the expected values in Factor XIII deficiency? - correct answer ✅Normal PT, APTT, and Fibrinogen What additional test is done in Factor XIII deficiency disease? - correct answer ✅5M urea solubility test (positive in Factor XIII deficiency). In what Factor deficiency disease, is there no history of bleeding? - correct answer ✅Factor XII and Prekallikrein deficiency A patient has a normal PT, TT, FIB and a prolonged APTT may have what factor deficiency disease? - correct answer ✅Factor XII deficiency disease
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How is DIC treated? - correct answer ✅Heparin, FFP, platelet concentrates, and cryoprecipitate DIC lab results include - correct answer ✅Decreased PLT Count; prolonged bleeding time. PT/PTT prolonged. Fibrinogen decreased.FSP/D-dimers positive. What is produced during DIC? - correct answer ✅Microthrombi DIC _______________ platelets and coagulation factors. - correct answer ✅Consumes What coagulation factor distinguishes Liver Disease from Vitamin K deficiency? - correct answer ✅VIII (normal to above normal in Liver Disease) How is vitamin K obtained? - correct answer ✅It must be ingested daily.
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Why is vitamin K essential for coagulation? - correct answer ✅It is necessary for the synthesis of Factors II, VII, IX, and X. How is vitamin K treated? - correct answer ✅Vitamin K therapy The PT and APTT lab results are what, in a vitamin K deficient patient? - correct answer ✅Prolonged Factors II, VII, IX, and X activity is what, in a vitamin K deficient patient? - correct answer ✅Decreased The Lupus Anticoagulant (LA) is directed against what part of the APTT reagent? - correct answer ✅Phospholipid component Lupus Anticoagulant (LA) is an example of what type of antibody? - correct answer ✅Antiphospholipid
