139
AbstrAct
Introduction: Wounds with dressing defects pose a great challenge when choosing a good treatment that may reduce the risk
of infection and promote granulation tissue formation. Objective: To demonstrate the usefulness of chlorhexidine digluconate
(CHG) for granulation tissue formation. Materials and methods: Eighteen wounds (16 patients) that met the inclusion criteria
were included. Wound cleansing was performed in outpatients with 20% CHG-impregnated cloths every 48-72h, until the proper
tissue granulation was achieved. Photographs of the clinical evolution of the wounds were taken. results: The adequate wound
granulation mean was of 9.2days (4-25days) regardless of wound size or presence of comorbidities. There were no clinical signs
of infection in any wound during the healing period. conclusions: CHG treatment is an appropriate method to be considered for
outpatient injuries, which reduces the hospital costs borne by the health-care system.
Level of Evidence: III.
Key words: chlorhexidine, wounds, granulation tissue, skin dressing defect.
Uso del gluconato de clorhexidina en la curación de heridas y su potencial formación de tejido
de granulación
rEsUMEn
Introducción: Las heridas con defectos de coberturas suponen un gran desafío a la hora de elegir un buen tratamiento que
reduzca el riesgo de infección e incremente la capacidad de granulación del tejido. El objetivo de este estudio fue demostrar la
utilidad del digluconato de clorhexidina para la granulación de tejidos. Materiales y Métodos: Se incluyeron 18 heridas de 16
pacientes que cumplían con los criterios de inclusión. Se realizaron curaciones ambulatorias con gasas embebidas en digluconato
de clorhexidina al 20%, cada 48-72 h, hasta lograr la adecuada granulación de tejido y se tomaron fotografías de la evolución
clínica de las heridas. resultados: Se observó una adecuada granulación de las heridas en una media de 9.2 días (rango 4-25
días), independientemente del tamaño o de la comorbilidades. Ninguna herida presentó signos clínicos de infección durante el
período de curación. conclusiones: El uso de digluconato de clorhexidina es un adecuado método por tener en cuenta para tratar
heridas, de forma ambulatoria, y así disminuir los costos hospitalarios del sistema de salud.
Palabras claves: Clorhexidina; heridas; tejido de granulación; defecto de cobertura.
nivel de Evidencia: IV
IntroductIon
The antiseptic properties of CHG have been known since the 1950s.1 CHG common applications include from
oral hygiene to preoperative surgical preparation and the prevention of hospital-acquired infections due to multi-
drug-resistant organisms.1,2 CHG is a bisbiguanide and exists as a cationic form at physiological pH that binds to
the negatively charged bacterial cell wall, altering the osmotic equilibrium of the bacterial cell and resulting in the
leakage of cytoplasmic contents.3,4 CHG is water-insoluble, thus the commercial CHG for clinical applications is
usually formulated with gluconic acid to form water-soluble salts.3,4
Use of chlorhexidine in wound healing
and granulation tissue formation
Edgar G. Wagner, Juan M. sala
Orthopedics Department, Hospital Regional de Comodoro Rivadavia, Chubut, Argentina
InVEstIGAcIÓn cLÍnIcA
Esta Revista está bajo una Licencia Creative Commons Atribución-NoComercial-Compartir
Obras Derivadas Igual 4.0 Internacional. (CC-BY-NC-SA 4.0).
Rev Asoc Argent Ortop Traumatol 2020; 85 (2): 139-146 • ISSN 1852-7434 (online)
Received on April 21st, 2019. Accepted after evaluation on November 30th, 2019 • Edgar G. Wagner, MD • edgar.gw@hotmail.com ‘https://orcid.org/0000-0001-9472-0014
How to cite this paper:
Wagner EG, Sala JM. Use of chlorhexidine in wound healing and granulation tissue formation. Rev Asoc Argent Ortop Traumatol 2020;85(2):139-146. https://doi.
org/10.15417/issn.1852-7434.2020.85.2.985
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